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IcoUpd visited hover text decoration none. Fl color promo a img, fl color promo img border noneimportant. Com i msnbc Components Art SITEWIDE newLogo half. Fl color promo padding top px. Migraine pill helps curb drinking without detox. New approach called promising, but side effects still a problem, study finds. CHICAGO A migraine pill seems to help alcoholics taper off their drinking without detox treatment, researchers report, offering a potential option for a hard to treat problem. The drug, Topamax, works in a different way than three other medications already approved for treating alcoholism. Side effects Addiction specialists not involved in the study said the findings are promising, although side effects such as trouble concentrating, tingling and itching caused about one in five people to drop out of the study. Drowsiness and dizziness are also problems. Clonazepam lethal dose!

Mark Willenbring of the National Institute on Alcohol Abuse and Alcoholism. And all the drinking variables changed in the right direction. The study, published in Wednesday s Journal of the American Medical Association, was funded by the maker of the drug, Johnson amp. The researchers also reported financial ties to the company. The study followed heavy drinkers for weeks. About half were randomly assigned to take Topamax, also called topiramate, in gradually increasing doses. All volunteers were encouraged but not required to stop drinking. At the start of the study, they drank, on average, standard drinks daily. That s about two six packs of beer each day, or two bottles of wine, or a pint of hard liquor. Simon winchester.

By the end of the study, of the people, or percent, who took Topamax had quit drinking entirely for seven weeks or more. That compared to six out of, or percent, in the placebo group. The Topamax group cut back to six drinks a day, on average, assuming everyone who dropped out of the study relapsed into heavy drinking. You can come in drinking a bottle of scotch a day and get treatment without detox, said Dr. Bankole Johnson of the University of Virginia, who led the study, which was conducted at U. Vancomycin iv infiltration?

The study didn t follow the drinkers long term, so it s unclear how many relapsed after they stopped taking the pill. But there were lasting effects for Tom Wolfe,, a carpenter from Earlysville, Va. Who said he has been sober for two years thanks to Topamax. He felt a little lightheaded at first until he got used to the drug. It got the monkey off my back. The drug works by inhibiting dopamine, the brain s feel good neurotransmitters that are involved in all addictions, said Stephen Dewey, a neuroscientist the Brookhaven National Laboratory, who was not involved in the study but does similar research.

Removing the stigma Willenbring, who wrote an accompanying editorial, predicts that a future pill, although probably not Topamax, will do for alcohol dependence what Prozac did for depression Remove the stigma. Prozac changed the nature of depression treatment years ago by allowing patients to see their family doctors for help, Willenbring said. An effective drug with few side effects could do the same for alcoholism treatment, he said. This is a huge market, Willenbring said. We re approaching a Prozac moment. With the drug maker s patent expiring next year, there won t be any big push to advertise it for alcoholism, Willenbring said. Alcoholism intense at regional drinking hubs. Officials target alcoholic energy drink ads. Anti addiction pill may curb smoking, drinking. Doctors are free to prescribe drugs for uses that have not been approved, but drug companies are prohibited by law from marketing drugs for these so called off label uses.

Sidney Wolfe, director of Public Citizen s health research group, sent a protest letter to the U. Food and Drug Administration questioning the promotion of Topamax for alcoholics by researchers funded by Ortho McNeil. The company dropped development of new uses for the drug in, but has continued to support some research.

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